It was carved out of Kaabong District and became operational on July 1, 2019.

It borders South Sudan and Kaabong District.

The population is 84,100, divided over 7 sub-counties and 3 town councils.

Karenga District is located in the vicinity of Kidepo Valley National Park.

It is the home District to the wildest of the African Game Parks, the Kidepo Conservation Area (Kidepo Valley National Park).