The district headquarters at Kibuku, are located approximately 53 kilometres (33 mi), by road, west of Mbale, the largest city in the sub-region.

Kibuku District was created by Act of the Ugandan Parliament, on 1 July 2010.

crop agriculture involves the following crops:[3] On 23 September 2015, 59 year old evangelist Samson Nfunyeku was murdered by Islamists in the village of Kalampete, Kibuku District.

Nfunyeku's attackers were opposed to his attempts to convert Muslims to Christianity.

One month later, Nfunyeku's sister, Mamwikomba Mwanika, a mother of eight, was also killed.