The district headquarters are located at Mayuge, approximately 38 kilometres (24 mi), by road, east of Jinja, Uganda's sixth largest city.

A large proportion of the district's surface area is open water of Lake Victoria.

The 2002 national census estimated the population of the district to be about 324,700 people, of whom 51.2% were female and 48.8% were male.

[2] Due to fertile soils and favorable climate, Mayuge District has great agricultural potential.

In recent times, bee keeping for production of honey, is becoming an accepted and practiced method of earning an income in the district.