The district headquarters at Bupoto are located approximately 40 kilometres (25 mi), by road, south-east of Mbale, the largest city of in the sub-region.

The district terrain in described as "hilly", and prone to soil erosion during the rainy season.

[2] The Bumbobi–Bubulo–Lwakhakha Road traverses the district in a general northwest to southeast direction.

[5] In 2009, the population of Namisindwa District (Bubulo County East), was estimated at approximately 177,000.

[2] In July 2016, the Uganda Bureau of Statistics (UBOS), estimated the district population at approximately 178,746.