[1][2][3] It appears to have a wide range of biological activities, which makes Oroidin a potential drug candidate for various diseases.
Combinations of pyrrolic building blocks and different cyclization dimerization fashions produce these polycyclic derivatives.
[10] Oroidin analogues have anticancer,[13] antiparasitic,[4] and antibiofilm[14] activities and therefore are a potential drug candidate for cancers, parasitic infections, and biofilm.
[13] Oroidin analogues appear to inhibit the growth of colon cancer cells the most, but the precise mechanism remains unclear.
[13] Oroidin further helps cancer treatment development by inhibiting multidrug resistance (MDR) activity.
[14] Therefore, the antibiofilm activity of Oroidin helps develop effective treatment for biofilm skin infection.
The sponges produce and secrete Oroidin (possibility with other secondary metabolites) in response to these ecological threats.
[10] However, molecules responsible for chemical defense appear to be evolutionary conserved and contribute to the success of marine sponges.