Otuke, where the district headquarters are located, lies approximately 66 kilometres (41 mi), by road, east of Lira, the largest city in the sub-region.

Otuke is among the nine districts that make up Lango sub-region, which consists of the districts listed below.

Lango sub-region was home to an estimated 1.5 million Langi, in 2002, according to the national census conducted that year.

The 2002 national census estimated the population of the district at approximately 62,000.

In 2012, the population of Otuke District was estimated at 86,000.