Sulfamide (IUPAC name: sulfuric diamide) is a compound with the chemical formula SO2(NH2)2 and structure H2N−S(=O)2−NH2.
Sulfamide was first prepared in 1838 by the French chemist Henri Victor Regnault.
[2] In organic chemistry, the term sulfamide may also refer to the functional group which consists of at least one organic group attached to a nitrogen atom of sulfamide.
Symmetric sulfamides can be prepared directly from amines, sulfur dioxide gas and an oxidant:[3] In this example, the reactants are aniline, triethylamine (Et3N, Et = ethyl group), and iodine.
The sulfamide functional group is an increasingly common structural feature used in medicinal chemistry.