Trifluoroacetone (1,1,1-trifluoroacetone) is an organofluorine compound with the chemical formula CF3C(O)CH3.

[2] Trifluoroacetone is produced from trifluoroacetoacetic acid, which is synthesized by condensation of ethyl trifluoroacetate and ethyl acetate: Hydrolysis of the keto-ester, followed by decarboxylation affords trifluoroacetone: Alternatively, addition of methylmagnesium iodide to trifluoroacetic acid gives the ketone according to this idealized equation:[2] Many studies report on the reactions of trifluoroacetone.

Hydrogenation of trifluoroacetone over platinum catalyst gives trifluoroisopropanol.

Similarly, alkylation with Grignard reagents provides a route to tertiary alcohols.

The derived chiral imine is used to prepare enantiopure α-trifluoromethyl alanines and diamines by a Strecker reaction followed by either nitrile hydrolysis or reduction.