The town of Zombo is the district's main municipal, administrative, and commercial center, Zombo District is bordered by Arua District to the north, Nebbi District to the east, and the Democratic Republic of the Congo to the south and west.

The town of Zombo, where the district headquarters are located, is approximately 70 kilometres (43 mi) south of Arua, the largest city in the sub-region.

[1] This is approximately 382 kilometres (237 mi), by road, northwest of Kampala, the capital and largest city of Uganda.

[3] The Alur people ethnic group comprise over 90% of the population.

[4] The district was created by Act of Parliament and became functional on 1 July 2009.