Zymosan is a beta-glucan with repeating glucose units connected by β-1,3-glycosidic linkages.

[1] Zymosan is prepared from yeast cell walls and consists of protein-carbohydrate complexes.

In macrophages, zymosan-induced responses include the induction of proinflammatory cytokines, arachidonate mobilization, protein phosphorylation, and inositol phosphate formation.

Zymosan A also raises cyclin D2 levels, suggesting a role for the latter in macrophage activation besides proliferation.

It potentiates acute liver damage after galactosamine injection, suggesting that certain types of nonparenchymal cells other than Kupffer cells are involved in zymosan action.