2021–22 EHF Champions League

Barça won the competition, defeating Łomza Vive Kielce on penalties in the final.

The knockout stage included four rounds: the playoffs, quarterfinals, and a final-four tournament comprising two semifinals and the final.

The four aggregate winners of the playoffs advanced to the quarterfinals, joining the top-two teams of Groups A and B.

The eight quarterfinalist teams were paired against each other in two-legged home-and-away matches, with the four aggregate winners qualifying to the final-four tournament.

[4] Although, in the final list announcement, the EHF said that if RK Vardar did not pay a fine for failing to play Champions League games in the previous season, they would be disqualified and replaced with RK Gorenje Velenje, who was the standby team.