Abad Santos Avenue is a major north–south arterial road located in the district of Tondo in northern Manila, Philippines.

The street was believed to have been named after a pre-Hispanic ruling clan of Tondo whose members included Don Agustin Manuguit, a local minister who participated in the Revolt of the Lakans.

In 1955, through Republic Act 1256, Manuguit Street was renamed in honor of José Abad Santos, Chief Justice of the Supreme Court of the Philippines, who was executed by the Japanese invading forces during World War II.

South of Bambang Street (Calle Trozo), Abad Santos traverses the Tutuban area that is home to Seng Guan Temple, Chiang Kai Shek College, the Philippine Cultural College, as well as General Hizon Elementary School and Gregorio del Pilar Elementary School.

The road ends at the junction with Recto Avenue (Calle Azcarraga), close to the Divisoria shopping district.