[1] It is a four-lane undivided arterial running parallel to Roxas Boulevard to the west and Taft Avenue to the east, from Pasay's border with Malate district in the north to Baclaran in Parañaque in the south.

The street is named for U.S. Governor-General of the Philippines Francis Burton Harrison.

It is a public transportation or medium-occupancy vehicle corridor frequented by intra-metropolitan jeepneys and mega-taxis.

This condition gives Harrison Street its relatively slow-moving, congested, and highly pedestrian character.

Harrison,[3] while those of the City of Manila and Parañaque have been renamed to Del Pilar Street and Quirino Avenue, respectively.