The road's name is also applied alternatively to Diego Cera Avenue in Las Piñas.

It then curves slightly upon reaching St. Andrew's Cathedral and straightens back as it heads south into barangay San Dionisio.

The road intersects with Victor Medina Street near the Kabihasnan Entrance to the Manila-Cavite Expressway and ends just a few hundred meters south as it enters barangay Manuyo Uno in Las Piñas, where it continues as Diego Cera Avenue.

Elpidio Quirino Avenue marks the original shoreline of Manila Bay in Parañaque pueblo as it existed during the Spanish colonial period.

Due to its accessibility to Cavite, it was also known as Cavite-Manila South Road, including the present-day Aguinaldo Highway.