It is a continuation of Elpidio Quirino Avenue from Parañaque and was originally a segment of Calle Real in Las Piñas.

The avenue marks the original shoreline of Manila Bay in Las Piñas as it existed during the Spanish colonial period.

[3] It was named after Fray Diego Cera de la Virgen del Carmen (1762–1832), the Spanish missionary from Huesca who designed and built the Bamboo Organ in 1824.

It intersects with Carlos Garcia Avenue Extension (C-5) and Naga Road before arriving in barangay Zapote.

Other landmarks along the avenue include Saint Joseph's Academy, Plaza Quezon, Las Piñas Catholic Cemetery, Maricielo Villas, and Zapote Public Market.