Paterio Aquino Avenue is the main street in Malabon, northern Metro Manila, Philippines.

It runs from Caloocan, beginning at the intersection with C-4 Road and terminating at F. Sevilla Boulevard at the Malabon City Hall roundabout.

The section west of Tonsuya Bridge in Barangays San Agustin and Tañong in Malabon is alternatively named Rizal Avenue Extension.

The six-lane undivided street houses several notable Malabon establishments, including the Malabon City Hall, San Bartolome Church, St. James Academy, Our Lady of Lourdes Cemetery, and Pescadores Restaurant.

The Metropolitan Manila Development Authority included it on the list of the metropolis's most flood-prone areas.