Samson Road is a major east–west street in Caloocan, northern Metro Manila, Philippines.

It is a continuation of Epifanio de los Santos Avenue (EDSA), linked to it via the Bonifacio Monument Roundabout (Monumento) to form a single through route.

[2][3] Samson Road, the main road in South Caloocan, officially begins at the Bonifacio Monument Roundabout (Monumento), the junction with EDSA, MacArthur Highway and Rizal Avenue Extension, and ends at the junction with A. Mabini and Marcelo H. Del Pilar Streets.

The road is generally commercial for most of its length, with a mix of high-density residential zones and a few schools.

[5] Its section west of Mabini and Del Pilar, now Gen. San Miguel Street, used to be the right-of-way alignment of tranvia's Manila–Malabon line until 1945.