The avenue is named after the nickname of Bonifacio Javier, a decorated guerrilla leader during World War II and former mayor of Mandaluyong.

It heads southeasterly, traversing the barangays of Old and New Zañiga and San José, crossing Primo Cruz Street before coming to a large roundabout called Maysilo Circle in Plainview.

At this roundabout, which houses the Mandaluyong City Hall complex and the Archdiocesan Shrine of the Divine Mercy, Boni intersects with F. Martinez Avenue and San Francisco Street.

It curves northeast past Maysilo Circle as it approaches a commercial district at Barangka Drive.

East of Barangka, the avenue becomes more commercial, with several retail outlets and condominium developments lining this section of Boni, where the Rizal Technological University is also situated.