Colonel Bonny Serrano Avenue (also spelled Boni Serrano Avenue; formerly named and still colloquially referred to as Santolan Road) is a major east–west thoroughfare in the Eastern Manila District of Metro Manila, Philippines, between San Juan and Quezon City.

It was named after the decorated Korean War hero Venancio "Bonny" Serrano.

The avenue runs from the border of barangays Corazón de Jesús, St. Joseph (Halo-Halo), Pasadena, and Little Baguio in San Juan to barangays Libís and Blue Ridge B near the Quezon City-Marikina border in the east.

It then intersects with Katipunan Avenue (C-5) via an overpass, passing through barangays Blue Ridge A, Blue Ridge B, and Saint Ignatius before terminating at Eulogio Rodriguez Jr. Avenue (C-5) in Libis near Camp Atienza where it continues as FVR Road to the Marikina–Infanta Highway in Calumpang, Marikina and Santolan, Pasig.

The road was renamed after Colonel Bonny Merioles Serrano in 1970, three months after the war hero's death.