General Luis Street is a two-to-four lane, major east-west thoroughfare running through Valenzuela, North Caloocan and Quezon City.

Heavy traffic is usually expected when traversing this road due to the concentration of tricycles and jeepneys, commercial establishments, warehouses and factories along and near the vicinity.

[2] Once called the Polo-Novaliches Road, it connects the towns of Novaliches (now mostly part of Quezon City) and Polo (now Valenzuela).

This segment of the road was renamed after one of Andrés Bonifacio's most trusted revolutionaries, General Luis Malinis, who was killed during the Battle of Novaliches in November 1896.

After passing through Mendoza Compound, it crosses the border to Kaybiga, part of North Caloocan.