The land on which the street lies used to be part of an estate owned by the family of José O. Vera, founder of Sampaguita Pictures and a Philippine senator.

[2] In the late 1950s, Quezon City mayor Norberto S. Amoranto convinced the Vera family to permit construction of the street through their property, part of a project to improve connectivity between Quezon City — at the time the capital of the Philippines — and the surrounding suburbs, particularly those headed to New Manila from Mandaluyong and Pasig.

[2] The family sold 1 hectare (110,000 sq ft) of land to the Quezon City government at a significant discount to facilitate the construction of the road, and its completion enabled direct access to Quezon City from eastern Metro Manila without needing to go through side streets or Epifanio de los Santos Avenue.

[2] In 2004, the street was renamed after Vera by the Sangguniang Panlungsod of Quezon City.

[3] The entire span of the road and its continuations have Class II paint-separated one-way bike lanes as part of the national government's Metropolitan Bike Lane Network.