C1-set domains are classical Ig-like domains resembling the antibody constant domain.

C1-set domains are found almost exclusively in molecules involved in the immune system, such as in immunoglobulin light and heavy chains, in the major histocompatibility complex (MHC) class I and II complex molecules,[2][3] and in various T-cell receptors.

HLA-B; HLA-B35; HLA-B57; HLA-C; HLA-CW; HLA-Cw; HLA-D;

HLA-DRw12; HLA-Dw12; HLA-E; HLA-F; HLA-G; HLA-G2.2; HLA-H; HLAC;

TRBV21-1; TRBV3-1; TRBV5-4; TRBV7-2; micB; This membrane protein–related article is a stub.