It runs north–south from the University of the Philippines Diliman, intersecting with Tandang Sora Avenue at its northernmost point, down to the Manila Philippines Temple of the Church of Jesus Christ of Latter-day Saints, intersecting with White Plains Avenue at its southernmost point.

An extension project, shelved by the government for the last six decades due to failed negotiations with private entities, has been revived by the Department of Public Works and Highways to address worsening traffic situations along Katipunan and Commonwealth Avenue, as well as Batasan–San Mateo Road.

In 2009, the SM Investments Group proposed to build a 31-story high-rise residential project called Stanford Residences on a 35,600 square metres (383,000 sq ft) site on Katipunan Avenue near the Santa Maria della Strada Parish Church, totalling over 1,316 residential and commercial units.

SP 918 S-2000), restricting the height of buildings in residential areas such as that part of Katipunan Avenue to 9 metres (30 ft).

[10] SM already had another high-rise project in progress on the other side of Katipunan Avenue, called Berkeley Residences, which was already 40% done by September 2009.

[11] Despite advisories warning against alcohol beverage distribution near schools along Katipunan Avenue, bar establishments remain a popular aspect of the area's nightlife.

[7] The tree-cutting was halted by an order from Malacañang, pending the return of then-President of the Philippines Gloria Macapagal Arroyo from an overseas trip.

[25] In 2002, a police officer was stabbed by the boyfriend of a girl whom he and his cousin had admitted harassing in a nightclub earlier that evening.

[27] In June 2007, police and carjackers suspected to be planning a bank robbery had a pre-dawn gunbattle along the avenue, leaving three of the alleged criminals dead.

The car in question had vehicle registration plates marking it as belonging to the National Prosecutor's League.