The entire length of the boulevard serves as the district boundary between Sampaloc in the north and Santa Mesa in the south, with the LRTA's Line 2 running along its median.

It is also served by the Santa Mesa railway station near the Polytechnic University of the Philippines campus on Hipodromo and Anonas Streets.

[2] The road, now known as Old Santa Mesa Street, was part of the original Calle Santa Mesa, up to the San Juan Bridge, wherein what is now the current alignment of Ramon Magsaysay Boulevard was later extended from Santol Street to Quezon City.

[5] In 1972, the R. Magsaysay Bridge II was built along the boulevard to facilitate the passage of vehicles crossing over the Philippine National Railways tracks.

It was later decommissioned in 2022 to make way for the NLEX Connector, which would cross between the boulevard's ground level and the elevated LRTA tracks.