[2][3] The street has four lanes for most of its course, beginning at the EDSA junction in Barangka Ilaya, Mandaluyong, where traffic emerges from the Boni Avenue tunnel, up to its easternmost point at the Shaw Boulevard junction at the boundary of barangays Kapitolyo and San Antonio in Pasig, adjacent to Ortigas Center.

En route, it passes through the Robinsons Cybergate Complex, where Forum Robinsons is located,[4] the United Laboratories plant, and Greenfield District, a mixed-use development south of Ortigas Center by the junction with Shaw Boulevard.

[citation needed] Pioneer Street is also the location of several new condominium developments, call center sites and a few strip malls.

In front of the former site of Forum Robinsons and the Cybergate complex, the street curves eastward.

The street soon enters the Pasig at Barangay Kapitolyo and finally terminates at the intersection with Shaw Boulevard.