It passes through the Paco and Pandacan districts and serves as a truck route between the Port Area and the South Luzon Expressway.

At Plaza Berde, the avenue then curves southwest to follow the alignment of the Philippine National Railways line, which merges with traffic from Paco-Santa Mesa Road (Tomas Claudio Street).

It follows a straight path south towards the border with Malate and is joined by Osmeña Highway.

It curves westwards past Adriatico Street until it meets its southern terminus at Roxas Boulevard, overlooking Manila Bay.

[6] The whole length of the highway that forms part of Circumferential Road 2 was later named in honor of the sixth President of the Philippines, Elpidio Quirino.