[2] It is the westernmost of the radial roads north of the Pasig River, running north–south close to the shoreline of Manila Bay.

When completed, the road would link the city of Manila with Navotas and the northern coastal provinces of Bulacan, Pampanga, and Bataan in Central Luzon.

North of the Estero de Marala, R-10 serves the Navotas Fish Port Complex and terminates at the Bangkulasi Bridge over the Tullahan River, where it continues towards South Caloocan and Quezon City as Circumferential Road 4 (C-4).

[6] Like Radial Road 1 and its segments, Roxas Boulevard and the Manila–Cavite Expressway, the highway would run along the coast of Manila Bay north of the Pasig River.

[7] The proposed highway would be built over fishponds and serve as flood barriers for the coastal provinces.