[1] Spanning some 56.51 kilometers (35.11 mi), it connects the cities and municipalities of Bacoor, Dasmariñas, Imus, Las Piñas, Manila, Parañaque, Pasay, Silang, and Tagaytay in Cavite and Metro Manila.

It serves the districts of Ermita and Malate, running underneath the Manila Light Rail Transit System Line 1 (LRT-1) towards Parañaque via Pasay.

This section of R-2 runs the entire length of Parañaque from Baclaran to San Dionisio.

It is the main north-south thoroughfare in the province of Cavite, linking Las Piñas in Metro Manila with Cavite, particularly the cities and municipalities of Bacoor, Imus, Dasmariñas, Silang, and Tagaytay.

R-2 ends at the Tagaytay Rotunda, which provides the famous view of the Taal Lake.