It stretches 1.6 kilometers (0.99 mi) from the former San Lazaro Hippodrome in Santa Cruz to Barrio Pritil in Tondo district.

Tayuman begins at an intersection with Lacson Avenue in the Santa Cruz district, fronting SM City San Lazaro.

It crosses Rizal Avenue, passing underneath the Tayuman LRT Station, where it continues past the headquarters of the Department of Health into the residential areas of Santa Cruz and Tondo.

The road has four lanes, two per direction, and is mostly lined with side streets and local businesses.

Numerous establishments line the road, like the Department of Health Central Office, Puregold Tayuman branch, Sentro ng Karunungan Library,[2] Archdiocesan Shrine of Espiritu Santo, Immaculate Conception Parish Church, and Tayuman Commercial Center.