The street links Eulogio Rodriguez Sr. Avenue in the village of Mariana in the south with Eugenio Lopez Drive (also known as Scout Albano Street) in South Triangle in the north and passes through Barangays Sacred Heart, Laging Handa, Kamuning, Obrero, and Kristong Hari.

Past the memorial rotunda, the avenue enters barangay South Triangle, ending at a T-intersection with Eugenio Lopez Drive by the ELJ Communications Center.

It is believed that the trees were planted by Tomas Morato himself, along with President Manuel Luis Quezon and journalist Alejandro Roces.

[6] In 1996, one of the deadliest nightclub fires occurred at the Ozone Disco Club on Tomas Morato and Timog Avenue.

In 2003, the street underwent a major renovation, with the sidewalk improved and railings installed along corners of the avenue to prevent double parking.