1OHC, 1OHD, 1OHE8555218294ENSG00000081377ENSMUSG00000033102O60729Q6PFY9NM_001351568NM_001351569NM_001351570NM_001122989NM_172587NP_001338498NP_001338499NP_001116461NP_766175Dual specificity protein phosphatase CDC14B is an enzyme that in humans is encoded by the CDC14B gene.

This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control.

Specifically, it is thought to fulfil this role by bundling and stabilising microtubules.

Alternative splicing of this gene results in 3 transcript variants encoding distinct isoforms.

[8] At the patho-physiological level, mice with CDC14B deletion were shown to exhibit early-onset ageing phenotypes.