2VSW, 3TG3, 4YR88082470686ENSG00000280962ENSG00000111266ENSMUSG00000030203Q9BY84n/aNM_030640NM_001048054NM_130447NM_181320NP_085143NP_085143.1n/aDual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.

[5][6][7][8] The activation of mitogen-activated protein kinase (MAPK) cascades transduces various extracellular signals to the nucleus to induce gene expression, cell proliferation, differentiation, cell cycle arrest, and apoptosis.

For full activation of MAPKs, dual-specificity kinases phosphorylate both threonine and tyrosine residues in MAPK TXY motifs.

MKPs are dual-specificity phosphatases that dephosphorylate the TXY motif, thereby negatively regulating MAPK activity.

This article on a gene on human chromosome 12 is a stub.