1109924000ENSG00000070778ENSMUSG00000021009Q16825Q62136NM_007039NM_001146199NM_011877NP_008970n/aTyrosine-protein phosphatase non-receptor type 21 is an enzyme that in humans is encoded by the PTPN21 gene.

PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation.

This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin.

This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains.

Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.