4JNB, 4KI91126680915ENSG00000081721ENSMUSG00000026659Q9UNI6Q9D0T2NM_007240NM_023173NP_009171NP_075662NP_001343414NP_001343415Dual specificity protein phosphatase 12 is an enzyme that in humans is encoded by the DUSP12 gene.

These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.

They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation.

Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.

This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase.