1RXD, 1XM2780319243ENSG00000112245ENSMUSG00000026064Q93096Q63739NM_003463NM_011200NP_003454NP_035330Protein tyrosine phosphatase type IVA 1 is an enzyme that in humans is encoded by the PTP4A1 gene.

[4][5] The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif.

PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes.

This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane.

Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis.