1ZZW, 2OUC, 2OUD, 3TG11122163953n/aENSMUSG00000039384Q9Y6W6Q9ESS0NM_007207NM_144728NM_144729NM_022019NP_009138NP_071302Dual specificity protein phosphatase 10 is an enzyme that in humans is encoded by the DUSP10 gene.

[4][5][6] Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.

They negatively regulate members of the MAPK superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation.

Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAPKs, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.

Its subcellular localization is unique; it is evenly distributed in both the cytoplasm and the nucleus.