1CWR, 1CWS, 1CWT, 1QB0, 1YM9, 1YMD, 1YMK, 1YML, 1YS0, 2A2K, 2IFD, 2IFV, 2UZQ, 3FQT, 3FQU, 4WH7, 4WH999412531ENSG00000101224ENSMUSG00000027330P30305P30306NM_001287522NM_001287524NM_004358NM_021872NM_021873NM_021874NM_212530NM_001111075NM_023117NP_001274451NP_001274453NP_004349NP_068658NP_068659NP_001104545NP_075606M-phase inducer phosphatase 2 is an enzyme that in humans is encoded by the CDC25B gene.
CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis.
The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2.
CDC25B has oncogenic properties, although its role in tumor formation has not been determined.
[6] CDC25B has been shown to interact with MAPK14,[7] Casein kinase 2, alpha 1,[8] CHEK1,[9] MELK,[10] Estrogen receptor alpha,[11] YWHAB,[12][13] YWHAZ,[12] YWHAH[12] and YWHAE.