[citation needed] On July 23, 2019, the two segments of the route were connected with the completion of the CAVITEX C-5 Link through a 2.2-kilometer (1.4 mi) flyover over the Skyway and the SLEX in 2019.

It is a 10-lane divided carriageway that serves as the main transportation corridor of Barangays Talipapa and Tandang Sora in Quezon City.

At the signaled junction with Mindanao Avenue, C-5 turns northeast as Congressional Avenue, a six-lane divided carriageway that serves as the main east-to-west transportation corridor of Barangays Bahay Toro, Culiat, Pasong Tamo, and Tandang Sora in Quezon City.

It runs for 1 kilometer (0.62 mi) from Barangay Matandang Balara, going around the University of the Philippines Diliman campus, up to the junction with Magsaysay Avenue.

Furthermore, Tandang Sora Avenue becomes a six-lane divided carriageway shortly after crossing Capitol Hills Drive, 350 meters (1,150 ft) south of the flyover.

At its junction with Bonny Serrano Avenue and FVR Road at the Libis Tunnel and Libis Flyover, C-5 then turns south as Eulogio S. Rodriguez Jr. Avenue, a 6.7-kilometer (4.2 mi), 10-lane divided road that serves as the main thoroughfare between Quezon City and Pasig.

Studies conducted by the PHIVOLCS revealed that a large portion of C-5 is built on top of the West Valley Fault.

[11][18] The project also involved building new alignments that would combine with old existing roads, including Eulogio Rodriguez Jr. Avenue, built in the 1960s.

The first phase of the C-5 Road from the South Luzon Expressway in Taguig to Ortigas Avenue, Pasig, which cost approximately ₱1.2 billion to construct, was officially inaugurated by President Fidel V. Ramos on December 30, 1994.

[21] On July 23, 2007, President Gloria Macapagal Arroyo announced in her State of the Nation Address that C-5 Road will be extended to northern Metro Manila up to the North Luzon Expressway in Valenzuela.

The opening of Segment 9 from NLEx to MacArthur Highway in Karuhatan, Valenzuela served as a preparation for the Holy Week season.

From September 2022 to April 2024, the C-5 Quirino Flyover, which crosses Diego Cera and Fruto Santos Avenues in Las Piñas, was constructed on the C-5 Extension.

In 2012, the Senate of the Philippines investigated the south extension project, which would pass several of Manny Villar's properties, such as Camella.

[25] In 1993, the Japan International Cooperation Agency (JICA) studied the proposed urban expressway system in Metro Manila.

[28] In 2014, under the Roadmap for Transport Infrastructure Development for Metro Manila and Its Surrounding Areas (Region III & Region IV-A; also known as the Metro Manila Dream Plan), the JICA study proposes a 46.7-kilometer (29.0 mi) expressway from the Manila–Cavite Expressway to San Jose Del Monte in Bulacan to pass above the existing C-5.

[30] In the late 2010s, NLEX Corporation (formerly Manila North Tollways Corporation) and CAVITEX Infrastructure Inc. submitted a proposal for C-5 Expressway, a 19-kilometer (12 mi) fully elevated expressway that would further decongest the existing C-5 and provide a fully controlled-access route between CAVITEX C-5 Link and NLEX Segment 8.2 (C-5 Link).

The kilometer count, which would be shown here in its approximate values, increments east and west of Harbor Link Interchange as it branches off NLEX Main.