[2] For traffic management purposes, the Metropolitan Manila Development Authority designates its Radial Road 5 separately, the same as the DPWH alignment.

[3] The route was originally planned outwards from Manila towards Rizal province, consisting of Victorino Mapa Street, P. Sanchez Street, Shaw Boulevard, and Pasig Boulevard until the Circumferential Road 5–Ortigas Avenue Interchange and Ortigas Avenue in Metro Manila.

East of EDSA, R-5 forms the southern boundary of the Ortigas Center business district and quickly enters the city of Pasig after crossing San Miguel Avenue.

It marks the boundary between barangays Kapitolyo and Bagong Ilog, running north–south towards the Pasig River before turning east towards C-5 by the Rizal Medical Center.

It crosses the Sierra Madre border between Rizal and Laguna and continues along the lakeshore from Mabitac south towards Pagsanjan.