2BIJ, 2BV5, 2CJZ8486719259ENSG00000110786ENSMUSG00000030854P54829P54830NM_032781NM_001163565NM_013643NP_116170NP_001157037NP_038671Protein tyrosine phosphatase non-receptor type 5 is an enzyme that in humans is encoded by the PTPN5 gene.

[10][11] Seven known targets of STEP have been identified as of 2015, including ERK1/2,[12][13] p38,[12] Fyn,[14] Pyk2,[15] PTPα,[16] and the glutamate receptor subunits GluN2B and GluA2.

[24] In AD and FXS mouse models, genetic reduction of STEP expression reverses many of the cognitive and behavioral deficits.

Thus, STEP levels or activity is decreased in Huntington's disease,[25][26] cerebral ischemia,[27] alcohol abuse,[28][29][30] and stress disorders.

[15][35] GlaxoSmithKline chose STEP as a new project for their Discovery Partnerships with Academia (DPAc) in 2014.