4KI1, 1T8C, 1T8D, 2H2R, 2H2T, 4EZM, 4G96, 4G9A, 4GI0, 4GJ0, 4GJX, 4GK1, 4GKO, 4J6J, 4J6K, 4J6L, 4J6M, 4J6N, 4J6P, 4J6Q220814128ENSG00000104921ENSMUSG00000005540P06734P20693NM_001207019NM_001220500NM_002002NM_001253747NM_013517NP_001193948NP_001207429NP_001993NP_001240676NP_038545CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels.

[6] The allergen responsible in dust mite allergy—Der p 1—is known to cleave CD23 from a cell’s surface.

Recent studies have shown that increased levels of soluble CD23 cause the recruitment of non-sensitised B-cells in the presentation of antigen peptides to allergen-specific B-cells, therefore increasing the production of allergen specific IgE.

[7] In flow cytometry, CD23 is helpful in the differentiation of chronic lymphocytic leukemia (CD23-positive) from mantle cell lymphoma (CD23-negative).

Paradoxically, Lymphomas arising from the mantle zone are generally negative for CD23, while most B-cell chronic lymphomocytic leukaemias are positive, allowing immunohistochemistry to distinguish these conditions, which otherwise have a similar appearance.