Dominican Republic competed at the 2023 Pan American Games in Santiago, Chile from October 20 to November 5, 2023.

Water skier Robert Pigozzi and equestrian Yvonne Losos de Muñiz were the country's flagbearers during the opening ceremony.

[1] Meanwhile, track athlete José González and karateka Pamela Rodríguez were the country's flagbearers during the closing ceremony.

[2][3] Dominican Republic qualified a men's team (of 24 athletes) by finishing fourth in the 2023 Central American and Caribbean Games.

[9] Key: Dominican Republic qualified four gymnasts in artistic (two men and two women) at the 2023 Pan American Championships.

[10] Dominican Republic qualified a men's team (of 14 athletes) by reaching the final of the 2023 Central American and Caribbean Games.

[22] Dominican Republic qualified 5 athletes (three men and two women) during the Pan American Games Qualification Tournament.