Guyana is scheduled to compete at the 2023 Pan American Games in Santiago, Chile from October 20 to November 5, 2023.

[1][a] Boxer Desmond Amsterdam and badminton athlete Priyanna Ramdhani were the country's flagbearers during the opening ceremony.

[1] Guyana qualified one male table tennis athlete at the final qualification tournament in Lima, Peru.

[11][12] Guyana would be later awarded a wildcard in the women's singles event, bringing the team size up to two athletes (one per gender).

[19] Guyana later received an additional quota for a women's weightlifter, meaning the team size was two athletes (one man and one woman).