Saint Kitts and Nevis competed at the 2023 Pan American Games in Santiago, Chile from October 20 to November 5, 2023.

Sprinter Nadale Buntin and tennis athlete Arina Valitova were the country's flagbearers during the opening ceremony.

The country won one medal, a bronze by Nadale Buntin in the men's 200 metres track and field event.

Saint Kitts and Nevis qualified four male track and field athletes.

This marked the country's first Pan American Games participation outside the sport of athletics.