Paraguay competed at the 2023 Pan American Games in Santiago, Chile from October 20 to November 5, 2023.

On 4 October 2023, the Paraguayan Olympic Committee officially named the team of 117 athletes (41 men and 76 women) competing in 22 sports.

[1] Athlete Derlis Ayala and cyclist Agua Marina Espínola were the country's flagbearers during the opening ceremony.

[2] Meanwhile, golfers Fabrizio Zanotti and Sofia Garcia were the country's flagbearers during the closing ceremony.

[12][13] Key: Paraguay qualified a women's team of 18 athletes after finishing fourth at the 2022 Copa América Femenina in Colombia.

[17] Paraguay qualified a team of two karatekas (one man and one woman) at the 2022 South American Games.

Paraguay qualified a team of four athletes (three men and one woman) through the 2023 South American Championship and the Special Qualification Event.