Honduras is scheduled to compete at the 2023 Pan American Games in Santiago, Chile from October 20 to November 5, 2023.

On October 12, 2023, a team of 42 athletes (31 men and 11 women) competing in nine sports was named by the Honduran Olympic Committee.

[1] Swimmer Marcos Moneta and tennis player Natalie Espinal were the country's flagbearers during the opening ceremony.

Honduras qualified one male mountain biker at the 2023 Pan American Championships.

Honduras qualified two athletes during the Pan American Games Qualification Tournament.