The PanAm Sports Independent Athletes competed at the 2023 Pan American Games in Santiago, Chile from October 20 to November 5, 2023.

The team was made up of athletes from Guatemala, whose NOC was suspended by International Olympic Committee during the games and was therefore not allowed to compete under its flag.

Sport climber Emilio Flores and swimmer Lucero Mejia were the teams flagbearers during the opening ceremony.

[1] Meanwhile, bowler Diego Aguilar and roller speed skater Dalia Soberanes were the delegation's flagbearers during the closing ceremony.

[5][6] Men Women Mixed Independent Athletes Team qualified a female pelotari through the 2023 Pan American Basque Pelota Tournament.

[19][20] Men Women Independent Athletes Team qualified a total of 17 shooters after the 2022 Americas Shooting Championships.

[21][22][23][24][25][26][27][28][29][30] Independent Athletes Team qualified a male climber by virtue of his IFSC world rankings.